Journal of Tissue Viability
Volume 19, Issue 4 , Pages 150-158 , November 2010

Effects of topical application of 10,000 IU heparin on patients with perineal dermatitis and second-degree burns treated in a public pediatric hospital

  • Julieta Maria Ferreira Chacon

      Affiliations

    • Graduate Program, Federal University of São Paulo (UNIFESP), Rua Napoleão de Barros 715, 4o andar, Vila Clementino, CEP 04024-002 São Paulo, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 11 5576 4118; fax: +55 11 5571 6579.
    • ,
  • Maria Lydia Mello de Andrea

      Affiliations

    • Pediatric Oncology Center, Darcy Vargas Pediatric Hospital, São Paulo, Brazil
    • ,
  • Leila Blanes

      Affiliations

    • Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
    • ,
  • Lydia Masako Ferreira

      Affiliations

    • Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

References 

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  10. Saliba MJ. Heparin efficacy in burns. II. Human thermal burn treatment with large doses of topical and parenteral heparin. Aerosp Med. 1970;41:1302–1306
  11. Saliba MJJ. Heparin in treatment of burns: a review. Burns. 2001;27:349–358
  12. Orgaes FAFS, Lyra MC, Rodrigues OF, Gonella HA. Estudo histopatológico do uso de heparina tópica em queimaduras por escaldo em ratos. Rev Soc Bras Cir Plast. 2007;22:39–44
  13. Barbosa ML, Gomes DR, Serra MC, Varges FRC, Muniz RT. Queimaduras em crianças e adolescentes: análise de 1302 casos. Rev Bras Queimaduras. 2002;2:25–30
  14. Pereima MJL, Leal M, Capella M, Goldberg P, Quaresma E, Araújo E, et al. Análise de 573 crianças com queimaduras internadas no Hospital Infantil Joana de Gusmão. Rev Bras Queimaduras. 2001;1:41–48
  15. Feijó FCS. Anestesia no paciente queimado. 123p In:  Lima EM,  Serra MCVF editor. Tratado de queimaduras. 1st ed. São Paulo: Atheneu; 2004;p. 123–129
  16. Bouloc A, Revuz J. Pain management and the use of analgesics in dermatology. Ann Dermatol Venereol. 2002;129:689–692
  17. Ruiz RO, Amaral BP, Augusto MF, Orgaes FS, Neto SP, Gonella HA. Comparative study: topical analgesia after facial peeling with tricholoroacetic acid (TCA) 30% utilizing distilled water and topical sodic heparin in spray (Alimax). Rev Bras Cir Plast. 2008;23:67–70
  18. Rossi LA, Ferreira E, Lucas R, Andrade D. Curativo do paciente queimado: uma revisão de literatura. Rev Esc Enferm USP. 2003;37:44–51
  19. Rak J, Weitz JI. Heparin and angiogenesis: size matters!. Arterioscler Thromb Vasc Biol. 2003;23:1954–1955
  20. Smorenburg SM. Inhibition of angiogenesis with heparin?. Haemostasis. 2001;31:25–29
  21. Norrby K. Heparin and angiogenesis: a low-molecular-weight fraction inhibits and a high-molecular-weight fraction stimulates angiogenesis systemically. Haemostasis. 1993;23:141–149
  22. Norrby K, Sorbo J. Heparin enhances angiogenesis by a systemic mode of action. Int J Exp Pathol. 1992;73:147–155
  23. Salas A, Sans M, Soriano A, Reverter JC, Anderson DC, Pique JM, et al. Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism. Gut. 2000;47:88–96
  24. Rosengart TK, Budenbender KT, Duenas M, Mack CA, Zhang QX, Isom OW. Therapeutic angiogenesis: a comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin. J Vasc Surg. 1997;26:302–312
  25. Plotz FB, van Oeveren W, Hultquist KA, Miller C, Bartlett RH, Wildevuur CR. A heparin-coated circuit reduces complement activation and the release of leukocyte inflammatory mediators during extracorporeal circulation in a rabbit. Artif Organs. 1992;16:366–370
  26. Hirish J, Rascheke R, Warkentin TE, Dale JE, Deykin D, Poller L. Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest. 1995;108:258S–275S
  27. Baer RL. Papaverine therapy in atopic dermatitis. J Am Acad Dermatol. 1985;13:806–808
  28. Dahl MV. Staphylococcus aureus and atopic dermatitis. Arch Dermatol. 1983;119:840–846
  29. Saliba MLJ, Dempsey WC, Kruggel JL. Large burns in humans: treatment with heparin. JAMA. 1993;225:261–269
  30. Barretto MGP. Terapia tópica com heparina no tratamento do paciente queimado. Rev Pratica Hospitalar. 2006;45:181–183

PII: S0965-206X(10)00036-7

doi: 10.1016/j.jtv.2010.03.003

Journal of Tissue Viability
Volume 19, Issue 4 , Pages 150-158 , November 2010

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