Journal of Tissue Viability
Volume 19, Issue 3 , Pages 106-115 , August 2010

A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

References 

  1. Carville K, Cuddigan J, Flatcher J, Fuchs P, Harding K, Ishikawa O, et al. Wound infection in clinical practice. An international consensus. London: MEP Ltd; 2008;p. 1–10
  2. Ikeda T, Tazuke S, Watanabe M. Interaction of biologically active molecules with phospholipid membranes. I. Fluorescence depolarization studies on the effect of polymeric biocide bearing biguanide groups in the main chain. Biochem Biophys Acta. 1983;735:380–386
  3. Koburger T, Müller G, Eisenbeiß W, Assadian O, Kramer A. Mikrobiozide Wirksamkeit von Polihexanid. GMS Krankenhaushyg Interdiszp. 2007;2(2):Doc44 (20071228)
  4. Müller G, Kramer A. Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother. 2008;61(6):1281–1287
  5. Wiegand C, Abel M, Kramer A, Müller G, Ruth P, Hipler U-C. Viability and proliferation of fibroblasts, keratinocytes and HaCaT-cells influenced by polihexanide. EWMA J. 2007;7(May):109
  6. Wiegand C, Abel M, Ruth P, Hipler U-C. Protective effect of polihexanide on HaCaT keratinocytes in co-culture with Staphylococcus aureus. EWMA J (Suppl). 2008;8(2):178
  7. Kramer A, Roth B, Muller G, Rudolph P, Klocker N. Influence of the antiseptic agents polihexanide and octenidine on FL-cells and on healing of experimental superficial aseptic wounds in piglets. A double-blind, randomised, stratified, controlled, parallel-group study. Skin Pharmacol Physiol. 2004;17:141–146
  8. Daeschlein G, Assadian O, Bruck JC, Meinl C, Kramer A, Koch S. Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds. Skin Pharmacol Physiol. 2007;20:292–296
  9. Schmit-Neuerburg KP, Bettag C, Schlickewei W, Fabry W, Hanke J, Renzing-Köhler K, et al. Effectiveness of an improved antiseptic in treatment of contaminated soft tissue wounds. Chirurg. 2001;72(1):61–71
  10. Disch AC, Matziolis G, Perka C. Two-stage operative strategy without local antibiotic treatment for infected hip arthroplasty: clinical and radiological outcome. Arch Orthop Trauma Surg. 2007;127(8):691–697
  11. Mulder GD, Cavorsi JP, Lee DK. Feature: polyhexamethylene biguanide (PHMB): an addendum to current topical antimicrobials. Wounds. 2007;19(7):173–182
  12. Bruckner M, Schwarz C, Otto F, Heillinger J, Wild T. Evaluation of cellulose and polyhexamethylene biguanide (Suprasorb® X+PHMB) in therapy of infected wounds. EWMA J (Suppl). 2008;8(2):54
  13. Mosti G, Mattaliano V. First Italian experience with a hydrobalanced cellulose-based wound dressing on hospital-patients with critically-colonized or locally infected chronic wounds. EWMA J (Suppl). 2008;8(2):168;Poster
  14. Mosti G, Mattaliano V. Successful therapy of critically-colonised or locally infected wounds with a new HydroBalanced cellulose-based wound dressing with polihexanide on out-patients. EWMA J (Suppl). 2008;8(2):169
  15. Pietsch T, Kraft R. Antimikrobielle Wirksamkeit ausgewählter Substanzen für die Wasserdesinfektion in Dentaleinheiten mit Biofilmen. Aseptica. 2006;12(4):3–4
  16. Harbs N, Siebert J. In vitro efficacy of octenidine and polihexanide against biofilms composed of Pseudomonas aeruginosa. GMS Krankenhaushyg Interdiszp. 2007;2(2):Doc.45 (20071228)
  17. Körber A, Seipp H-M, Hofmann S. Efficacy of different wound dressings on artificial plaques of fibrin. EWMA J (Suppl). 2008;8(2):261
  18. Wiegand C, Abel M, Ruth P, Hipler U-C. Polihexanide inhibits the formation of ROS/RNS in vitro. EWMA J (Suppl). 2008;8(2):178
  19. Schmidtchen A, Davoudi M, Andersson E. Potent antibacterial effects of polyhexamethylenebiguanide on common chronic ulcer-derived bacteria. Abstracts 13th Conf Europ Wound Manag Assoc… (EWMA) Pisa; 2003. p. 70.
  20. Bolton L, Oleniacz W, Constantine B, Kelliher BO, Jensen D, Means B, et al. Repair and antibacterial effects of topical antiseptic agents in vivo. In:  Maibach H,  Lowe I editor. Models in Dermatology 2. Basel: Karger; 1985;p. 145–158
  21. Kallenberger A, Kallenberger C, Willenegger H. Experimentelle Untersuchungen zur Gewebeverträglichkeit von Antiseptika. Hyg Med. 1991;16:383–395
  22. Seipp HM, Hofmann S, Hack A, Skowronsky A, Hauri A. Wirksamkeit verschiedener Wundspüllösungen gegenüber Biofilmen. J Wound Healing (ZfW). 2005;4:160–164
  23. Schnuch A, Geier J, Uter W, Basketter DA, Jowsey IR. The biocide polyhexamethylene biguanide remains an uncommon contact allergen. Contact Dermatitis. 2007;56(4):235–239
  24. Schnuch A, Geier J, Brasch J, Fuchs T, Pirker C, Schulze-Dirks A, et al. Polyhexamethylenebiguanide: a relevant contact allergen?. Contact Dermatitis. 2000;42(5):302–303
  25. Werner HP, Kramer A. Mikrobiologische Anforderungen an lokale Antiinfektiva unter spezieller Berücksichtigung der antiinfektiven Wundbehandlung. In:  Kramer A,  Wendt M,  Werner HP editor. Möglichkeiten und Perspektiven der klinischen Antiseptik. Wiesbaden: mhp; 1995;p. 26–30
  26. Rosin M, Welk A, Kocher T, Majic-Todt A, Kramer A, Pitten FA. The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque regrowth. J Clin Periodontol. 2002;98:392–399
  27. Kramer A, Roth B. Polihexanid. In:  Kramer A,  Assadian O editor. Wallhäußers Praxis der Sterilisation, Desinfektion, Antiseptik und Konservierung. Stuttgart: Thieme; 2008;p. 789–793
  28. Roth B, Assadian O, Wurmitzer F, Kramer A. Wundinfektionen nach antiseptischer Primärversorgung kontaminierter traumatischer Wunden mit Polihexanid, PVP-Iod bzw. Wasserstoffperoxid. GMS Krankenhaushyg Interdiszp. 2007;2(2):http://www.egms.de/en/journals/dgkh/2007-2/dgkh000091.shtmlDoc58
  29. Frieß W, Metzmacher I, Wild T. Die Bedeutung von Kollagen und Kollagenasen in der Wundheilung. In:  Wild T editors. Manual der Wundheilung. Wien, New York: Springer; 2007;p. 89–98
  30. Deutscher Arzneimittel-Codex DAC/Neues Rezeptur-Formularium NRF. Govi-Verlag Eschborn; 2008;
  31. Müller G, Kramer A, Karkour Y. Biokompatibilitätsindex silberhaltiger Wundantiseptika. GMS Krankenhaushyg Interdiszip. 2006;1(1):Doc31

PII: S0965-206X(10)00039-2

doi: 10.1016/j.jtv.2010.06.002

Journal of Tissue Viability
Volume 19, Issue 3 , Pages 106-115 , August 2010